2020 – 2022
Brianna M. Vickerman, Colin P. O’Banion, Xianming Tan, and David S. Lawrence “Light-Controlled Release of Therapeutic Proteins from Red Blood Cells using a Photoactivatable Hemolytic Peptide”, ACS Central Science, 2021, 7, 93 - 103.
Brianna M. Vickerman, Emilia M. Zywot, Teresa K. Tarrant, and David S. Lawrence “Taking Phototherapeutics from Concept to Clinical Launch”, Nature Reviews Chemistry, 2021, 5, 816 - 34.
Matthew M. Anttila, Brianna M. Vickerman, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton, “Photoactivatable Reporter to Perform Multiplexed and Temporally Controlled Measurements of Kinase and Protease Activity in Single Cells”, Analytical Chemistry, 2021, 93, 16664 - 72.
Emilia M. Zywot, Natalia Orlova, Song Ding, Rishi R. Rampersad, Emily M. Rabjohns, Victoria A. Wickenheisser, Qunzhao Wang, Joshua G. Welfare, Lauren Haar, Amanda M. Eudy, Teresa K. Tarrant, and David S. Lawrence “Light‐Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation”, Advanced Therapeutics, 2022, 5, 2100159.
Joshua G. Welfare, Michael J. Mortelliti, Caylie A. McGlade, Timothy W. Hartman, Jillian L. Dempsey, and David S. Lawrence, “Assessment of Photoreleasable Linkers and Light-Capturing Antennas on a Photoresponsive Cobalamin Scaffold”, Journal of Organic Chemistry, 2022, 87, 5076 – 5084.
Christopher I. Kong, Joshua G. Welfare, Hannah Shenouda, Olivia R. Sanchez-Felix, Joel B. Floyd, Jr, Robert C. Hubal, Jerry S. Heneghan, and David S. Lawrence, “Virtually Bridging the Safety Gap Between the Lecture Hall and the Research Laboratory”, Journal of Chemical Education, 2022, 5, 1982 – 1989.
2019 – 2020
Marissa L. Cann, Laura E. Herring, Lauren L. Haar, Thomas S. K. Gilbert, Dennis Goldfarb, Kristy L. Richards, Lee M. Graves, and David S. Lawrence “Dasatinib is preferentially active in the activated B-cell subtype of diffuse large B-cell lymphoma”, Journal of Proteome Research, 2019, 18, 522 - 34.
Colin P. O’Banion, Brianna M. Vickerman, Lauren Haar, and David S. Lawrence “Local cAMP Generation by Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases”, Cell Chemical Biology, 2019, 26, 1393 - 406.
Lauren L. Haar, David S. Lawrence, and Robert M. Hughes “Optogenetic Perturbation of the Biochemical Pathways that Control Cell Behavior”, Methods in Enzymology: Chemical and Synthetic Biology Approaches to Understand Cellular Functions, 2019, 621, 310 - 328.
Colin P. O’Banion, Anwesha Goswami, David S. Lawrence “Design, Construction, and Validation of Optogenetic Proteins”, Methods in Enzymology: Chemical and Synthetic Biology Approaches to Understand Cellular Functions, 2019, 621, 171 - 90.
Angela Proctor, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton “Selection and Optimization of Enzyme Reporters for Chemical Cytometry”, Methods in Enzymology: Chemical and Synthetic Biology Approaches to Understand Cellular Functions, 2019, 621, 221 - 248.
David J. Hill, Olivia F. Williams, Danianne P. Mizzy, Therese F. Triumph, Catherine R. Brennan, Dawn C. Mason, and David S. Lawrence “Introduction to Laboratory Safety for Graduate Students: An Active Learning Endeavor”, Journal of Chemical Education, 2019, 96, 652 - 9.
Victoria A. Wickenheisser, Emilia M. Zywot, Emily M. Rabjohns, Hyun H. Lee, David S. Lawrence, and Teresa K. Tarrant “Low-Level Laser Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease”, Current Allergy and Asthma Reports, 2019, 19, doi: 10.1007/s11882-019-0869-z.
Christina M. Marvin, Song Ding, Rachel E. White, Natalia Orlova, Qunzhao Wang, Emilia M. Zywot, Lauren Haar, Teresa K. Tarrant, Paul A. Dayton, and David S. Lawrence “On Command Drug Delivery via Cell-Conveyed Phototherapeutics”. Small, 2019, e1901442, doi: 10.1002/smll.201901442.
Kshitij Parag-Sharma, Colin P. O’Banion, Erin C. Henry, Adele M. Musicant, John L. Cleveland, David S. Lawrence, and Antonio L. Amelio “Engineered BRET-Based Biologic Light Sources Enable Spatio-Temporal Control Over Diverse Optogenetic Systems", ACS Synthetic Biology, 2020, 9, 1 - 9.
2017 – 2018
Vickerman BM, Anttila MM, Petersen BV, Allbritton NL, Lawrence DS. Design and Application of Sensors for Chemical Cytometry ACS Chem Biol. 2018 Jul 20;13(7):1741-1751.
Ding S, O'Banion CP, Welfare JG, Lawrence DS. Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution. Cell Chem Biol. 2018 Jun 21;25(6):648-658.
O'Banion CP, Lawrence DS. Chembiochem. Optogenetics: A Primer for Chemists. 2018 Jun 18;19(12):1201-1216.
O'Banion CP, Priestman MA, Hughes RM, Herring LE, Capuzzi SJ, Lawrence DS. Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. Cell Chem Biol. 2018 Jan 18;25(1):100-109.
Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S. Lawrence, John B. Buse, and Zhen Gu, “Red Blood Cells for Glucose Responsive-Insulin Delivery”, Advanced Materials, 2017, 29, 1606617.
2015 – 2016
Melanie A. Priestman, Qunzhao Wang, Finith E. Jernigan, Ruma Chowdhury, Marion Schmidt, and David S. Lawrence "Multicolor Monitoring of the Proteasome’s Catalytic Signature," ACS Chemical Biology, 2015, 10, 433 – 40.
Zachary L. Rodgers, Robert M. Hughes, Laura M. Doherty, Jennifer R. Shell, Brian P. Molesky, Alexander M. Brugh, Malcolm D. E. Forbes, Andrew M. Moran, and David S. Lawrence "B12-Mediated, Long Wavelength Photo-polymerization of Hydrogels," J. Amer. Chem. Soc. 2015, 137, 3372 – 80.
Robert M. Hughes, David J. Freeman, Kelsey N. Lamb, Rebecca M. Pollet, Weston J. Smith, and David S. Lawrence, "Optogenetic Apoptosis: Light-Triggered Cell Death," Angewandte Chemie International Edition, 2015, 54, 12064 - 8.
Thomas A. Shell and David S. Lawrence, "Vitamin B12: A Tunable, Long Wavelength, Light-Responsive Platform for Launching Therapeutic Agents," Accounts of Chemical Research, 2015, 48, 2866 - 74.
Colin P. O’Banion, Luong T. Nguyen, Qunzhao Wang, Melanie A. Priestman, Stephen P. Holly, Leslie V. Parise, and David S. Lawrence, "The Plasma Membrane as a Reservoir, Protective Shield, and Light-Triggered Launch Pad for Peptide Therapeutics," Angewandte Chemie International Edition, 2016, 55, 950 - 54.
Abigail H. Turner, Michael S. Lebhar, David S. Lawrence, and Nancy L. Allbritton, "A Conformationally-Constrained Tyrosine Analog that is Dephosphorylation-Resistant Enables In Cellulo Measurement of Tyrosine Kinase Activity by Directed Metabolic Cytometry," ACS Chemical Biology, 2016, 11, 355-62.
Zachary L. Rodgers, Thomas A. Shell, Alexander M. Brugh, Hannah L. Nowotarski, Malcolm D.E. Forbes, and David S. Lawrence, "Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins," Inorganic Chemistry, 2016, 55, 1962-69.
Emilie R. Mainz, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton, “An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells”, Angewandte Chemie International Edition, 2016, 55, 13095 - 8.
Angela Proctor, Imola G. Zigoneanu, Qunzhao Wang, Christopher E. Sims, David S. Lawrence, and Nancy L. Allbritton, “Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells”, Analyst, 2016, 141, 6008 - 17.
Robert M. Hughes, Christina M. Marvin, Zachary L. Rodgers, Song Ding, Nathan P. Oien, Weston J. Smith, and David S. Lawrence, “Photo-Triggered Secretion of Membrane Compartmentalized Bioactive Agents”, Angewandte Chemie International Edition, 2016, 55, 16080 - 3. Received “Hot Paper” designation.
2014
Thomas A. Shell, Jennifer R. Shell, Zachary L. Rodgers, and David S. Lawrence "Tunable Visible and Near IR Photoactivation of Light-Responsive Compounds," Angewandte Chemie International Edition, 2014, 53, 875 - 8. Received VIP designation.
Nathan P. Oien, Luong T. Nguyen, Finith E. Jernigan, Melanie A. Priestman, and David S. Lawrence "Long Wavelength Monitoring of Protein Kinase Activity," Angewandte Chemie International Edition, 2014, 53, 3975 - 8.
Angela Proctor, Gabriela Herrera, Qunzhao Wang, David S. Lawrence, Jen Jen Yeh, and Nancy L. Allbritton "Measurement of Protein Kinase B Activity in Single Primary Human Pancreatic Cancer Cells," Analytical Chemistry, 2014, 86, 4573 - 80.
Weston J. Smith, Nathan P. Oien, Robert M. Hughes, Christina M. Marvin, Zachery L. Rodgers, Junghyun Lee, and David S. Lawrence "Cell-Mediated Assembly of Phototherapeutics," Angewandte Chemie International Edition, 2014, 53, 10945 - 8.
Robert M. Hughes and David S. Lawrence "Optogenetic Engineering: Light-Directed Cell Motility," Angewandte Chemie International Edition, 2014, 53, 10904 - 7.
2013
Qunzhao Wang and David S. Lawrence "Multicolor Visualization of Protein Arginine Deiminase-Catalyzed Citrullination," Angewandte Chemie International Edition, 2013, 52, 2323 – 5.
Finith Jernigan and David S. Lawrence "A Broad Spectrum Dark Quencher: Construction of Multiple Colour Protease and Photolytic Sensors," Chemical Communications, 2013, 49, 6728 - 30.
Daniel R. Larson, Christoph Fritzsch, Liang Sun, Xiuhau Meng, David Lawrence, and Robert H. Singer "Light-Activated Receptor-Mediated Transcription in Single Cells," eLife, 2013, 2: e00750.
Ryan M. Phillips, Eric Bair, David S. Lawrence, Christopher E. Sims, and Nancy L. Allbritton "Measurement of Protein Tyrosine Phosphatase Activity in Single Cells by Capillary Electrophoresis," Analytical Chemistry, 2013, 85, 6136 - 42.
Jennifer R. Shell and David S. Lawrence "Probes of Mitochondrial cAMP-Dependent Protein Kinase," Biochim. Biophys. Acta 2013, 1834, 1359 - 63.
Luong T. Nguyen, Nathan P. Oien, Nancy L. Allbritton, and David S. Lawrence "Lipid Pools as Photolabile Protecting Groups": Design of Light-Activatable Bioagents," Angewandte Chemie International Edition, 2013, 52, 9936 - 9. Received VIP designation.
2012
Jennifer R. Shell and David S. Lawrence "Proteolytic Regulation of the Mitochondrial cAMP-Dependent Protein Kinase," Biochemistry," 2012, 51, 2258 - 64.
Angela Proctor, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton "Metabolism of Peptide Reporters in Cell Lysates and Single Cells," Analyst, 2012, 137, 3028 – 38.
Melanie A. Priestman, Thomas A. Shell, Liang Sun, Hsien-Ming Lee, and David S. Lawrence "Merging of Confocal and Caging Technologies: Selective Three Color Communication with Profluorescent Reporters," Angewandte Chemie International Edition, 2012, 51, 7684 - 7.
Shen Zhang, Lan Chen, L., David S. Lawrence, and Zhong-Yin Zhang. "A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase Inhibitors," Methods in Molecular Biology, 2012, 928, 53 - 65.
Angela Proctor, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton "Development of a Peptidase-Resistant Substrate for Single-Cell Measurement of Protein Kinase B Activation," Analytical Chemistry, 2012, 84, 7195 – 202.
Weichen Xu, Nancy L. Allbritton, and David S. Lawrence "Src Kinase Regulation in Progressively Invasive Cancer," PLoS One, 2012, 7, e48867.
2010 – 2011
Melanie A. Priestman and David S. Lawrence "Light-Mediated Remote Control of Signaling Pathways" Biochim. Biophys. Acta 2010, 1804, 1547 - 58.
Aya Wakata, Hsien-ming Lee, Alexei Toutchkine, Marion Schmidt, and David S. Lawrence "Simultaneous Fluorescent Monitoring of Proteasomal Subunit Catalysis" J. Amer. Chem. Soc., 2010, 132, 1578 -82.
Hsien-ming Lee, Melanie A. Priestman, and David S. Lawrence "Light-Mediated Spatial Control Via Photolabile Fluorescently Quenched Peptide Cassettes" J. Amer. Chem. Soc. 2010, 132, 1446 - 7.
Vyas Sharma, Finith Jernigan, Jennifer R. Shell, Richard A. Agnes, and David S. Lawrence "Suborganelle Sensing of Mitochondrial cAMP-Dependent Protein Kinase Activity", J. Amer. Chem. Soc, 2010, 132, 6075 - 80.
Qunzhao Wang, Eric I. Zimmerman, Alexei Toutchkine, Timothy D. Martin, Lee M. Graves, and David S. Lawrence "Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia," ACS Chemical Biology, 2010, 5, 887 - 95.
Thomas A. Shell and David S. Lawrence "A New Trick (Hydroxyl radical Generation) for An Old Vitamin (B12)2010," J. Amer. Chem. Soc., 2011, 133, 2148 – 50.
Melanie A. Priestman, Liang Sun, and David S. Lawrence "Dual Wavelength Photoactivation of cAMP- and cGMP-Dependent Protein Kinase Signaling Pathways," ACS Chemical Biology, 2011, 6, 377 - 84.
Hsien-ming Lee, Weichen Xu, and David S. Lawrence "Construction of a Photoactivatable Profluorescent Enzyme Via Propinquity Labeling," J. Am. Chem. Soc. 2011, 133, 2331 - 3.
Research Areas
Light Activated Drugs
Light has been used, in conjunction with light-responsive agents, to control the biochemistry of cells, manipulate the behavior of organisms, and treat diseases such as cancer. We have designed a host of light-responsive sensors, inhibitors...
Read MoreCellular Cyborgs
A typical human brain contains a hundred trillion synapses, which is three orders of magnitude larger than the hundred billion galaxies in the observable universe. This complexity represents one of the many challenges...
Read MoreMulticolor Monitoring
More than 150,000 people will be diagnosed with a hematological malignancy, for example leukemia, this year, joining the greater than 1,000,000 people living in the United States with these diseases. Although there has been significant...
Read MoreOptogenetic Tools
The ability to control the biochemistry and behavior of cells and organisms with a flash of light has elicited widespread attention, especially in the area of neurological diseases. Switching on the activity of a specific protein in a...
Read MorePersonalized Pharmacology
One of the most compelling issues in preclinical and clinical drug discovery is the ability to accurately monitor drug action and patient responsiveness. For example, the heterogeneity of breast cancers requires that we create a means by...
Read More